Buspirone EP Impurity A Dibromo salt CAS 20980-22-7 (free base)
| CAS No. | 20980-22-7 (free base) |
| Molecular Formula | C8H12N4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 245.12 g/mol gives Buspirone EP Impurity A Dibromo salt distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Buspirone EP Impurity A Dibromo salt (CAS 20980-22-7 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C8H12N4HBr and a molecular weight of 245.12 g/mol.
The molecular framework of Buspirone EP Impurity A Dibromo salt (C8H12N4HBr) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12N4 2*HBr |
| Molecular Weight | 245.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Buspirone Standards
- Buspirone impurity 01 (CAS 105496-33-1)
- Buspirone EP Impurity K (CAS 1075-89-4)
- Buspirone EP Impurity A-d8 (Buspirone USP Related Compound A-d8) (CAS 1309283-31-5)
- Buspirone Impurity 9 (CAS 13220-24-1)
- Buspirone Impurity 21 (CAS 137583-05-2)
- Buspirone Impurity 24 (CAS 1800242-04-9)
- Buspirone Impurity 20 (CAS 1821194-01-7)
- Buspirone Impurity 23 (CAS 20261-27-2)
Recommended Standards
- Ertugliflozin impurity 15 (CAS CATO-C4X-301115)
- Phentolamine Mesilate EP Impurity A (CAS 2724727-52-8（free base）)
- Ropivacaine Impurity 26 (CAS CATO-C4X-175326)
- Desacetyl Rifampicin Quinone (CAS 65110-92-1)
- 1-(4-Chlorophenyl)-3-(1-(3,4-dichlorobenzoyl)-1H-pyrazol-3-yl)pyridazin-4(1H)-one (CAS 318498-09-8)
- 4,7-Dibromo-1H-pyrrolo[2,3-c]pyridine (CAS 619331-71-4)
- 4-Pentenal (CAS 2100-17-6)
- 2-Ethoxy-3,5-dimethylbenzoic acid (CAS 1216091-64-3)
- 4-Bromo-1-propyl-1H-pyrazol-3-amine hydrobromide (CAS 1431966-23-2)
- Vialox Peptide(Pentapeptide-3) diacetate (CAS 725232-44-0)
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